Genetics: Analysis and Principles 7th Edition by Robert J. Brooker, ISBN-13: 978-1260240856

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Genetics: Analysis and Principles 7th Edition by Robert J. Brooker, ISBN-13: 978-1260240856

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• Publisher: ‎ McGraw Hill; 7th edition (January 9, 2020)
• Language: ‎ English
• 880 pages
• ISBN-10: ‎ 1260240851
• ISBN-13: ‎ 978-1260240856

Genetics: Analysis and Principles is a one-semester, introductory genetics textbook that takes an experimental approach to understanding genetics. By weaving one or two experiments into the narrative of each chapter, students can simultaneously explore the scientific method and understand the genetic principles that have been learned from these experiments. The pedagogy of Genetics: Analysis & Principles has been designed to foster student learning. Instead of being a collection of facts and figures,this text is intended to be an engaging and motivating textbook in which formative assessment allows students to move ahead and learn the material in a productive way.

Table of Contents:

Title Page

Copyright Page

Brief Contents

Contents

About The Author

Dedication

Preface

Connect Page

Part I Introduction

Chapter 1 Overview of Genetics

1.1 The Molecular Expression of Genes

1.2 The Relationship Between Genes and Traits

1.3 Fields of Genetics

1.4 The Science of Genetics

Part II Patterns of Inheritance

Chapter 2 Mendelian Inheritance

2.1 Mendel’s Study of Pea Plants

2.2 Law of Segregation

2.3 Law of Independent Assortment

2.4 Studying Inheritance Patterns in Humans

2.5 Probability and Statistics

Chapter 3 Chromosome Transmission During Cell Division and Sexual Reproduction

3.1 General Features of Chromosomes

3.2 Cell Division

3.3 Mitosis and Cytokinesis

3.4 Meiosis

3.5 Sexual Reproduction

3.6 The Chromosome Theory of Inheritance and Sex Chromosomes

Chapter 4 Extensions of Mendelian Inheritance

4.1 Overview of Simple Inheritance Patterns

4.2 Dominant and Recessive Alleles

4.3 Environmental Effects on Gene Expression

4.4 Incomplete Dominance, Overdominance, and Codominance

4.5 Genes on Sex Chromosomes

4.6 Sex-Influenced and Sex-Limited Inheritance

4.7 Lethal Alleles

4.8 Understanding Complex Phenotypes Caused by Mutations in Single Genes

4.9 Gene Interactions

Chapter 5 Non-Mendelian Inheritance

5.1 Maternal Effect

5.2 Epigenetics: Dosage Compensation

5.3 Epigenetics: Genomic Imprinting

5.4 Extranuclear Inheritance

Chapter 6 Genetic Linkage and Mapping in Eukaryotes

6.1 Overview of Linkage

6.2 Relationship Between Linkage and Crossing Over

6.3 Genetic Mapping in Plants and Animals

6.4 Genetic Mapping in Haploid Eukaryotes

6.5 Mitotic Recombination

Chapter 7 Genetic Transfer and Mapping in Bacteria

7.1 Overview of Genetic Transfer in Bacteria

7.2 Bacterial Conjugation

7.3 Conjugation and Mapping via Hfr Strains

7.4 Bacterial Transduction

7.5 Bacterial Transformation

7.6 Medical Relevance of Horizontal Gene Transfer

Chapter 8 Variation in Chromosome Structure and Number

8.1 Microscopic Examination of Eukaryotic Chromosomes

8.2 Changes in Chromosome Structure: An Overview

8.3 Deletions and Duplications

8.4 Inversions and Translocations

8.5 Changes in Chromosome Number: An Overview

8.6 Variation in the Number of Chromosomes Within a Set: Aneuploidy

8.7 Variation in the Number of Sets of Chromosomes

8.8 Natural and Experimental Mechanisms That Produce Variation in Chromosome Number

Part III Molecular Structure AND Replication of the Genetic Material

Chapter 9 Molecular Structure of DNA and RNA

9.1 Identification of DNA as the Genetic Material

9.2 Overview of DNA and RNA Structure

9.3 Nucleotide Structure

9.4 Structure of a DNA Strand

9.5 Discovery of the Double Helix

9.6 Structure of the DNA Double Helix

9.7 RNA Structure

Chapter 10 Molecular Structure of Chromosomes and Transposable elements

10.1 Organization of Functional Sites Along Bacterial Chromosomes

10.2 Structure of Bacterial Chromosomes

10.3 Organization of Functional Sites Along Eukaryotic Chromosomes

10.4 Sizes of Eukaryotic Genomes and Repetitive Sequences

10.5 Transposition

10.6 Structure of Eukaryotic Chromosomes in Nondividing Cells

10.7 Structure of Eukaryotic Chromosomes During Cell Division

Chapter 11 DNA Replication

11.1 Structural Overview of DNA Replication

11.2 Bacterial DNA Replication: The Formation of Two Replication Forks at the Origin of Replication

11.3 Bacterial DNA Replication: Synthesis of New DNA Strands

11.4 Bacterial DNA Replication: Chemistry and Accuracy

11.5 Eukaryotic DNA Replication

Part IV Molecular Properties of Genes

Chapter 12 Gene Transcription and RNA Modification

12.1 Overview of Transcription

12.2 Transcription in Bacteria

12.3 Transcription in Eukaryotes

12.4 RNA Modification

12.5 A Comparison of Transcription and RNA Modification in Bacteria and Eukaryotes

Chapter 13 Translation of mRNA

13.1 The Genetic Basis for Protein Synthesis

13.2 The Relationship Between the Genetic Code and Protein Synthesis

13.3 Experimental Determination of the Genetic Code

13.4 Structure and Function of tRNA

13.5 Ribosome Structure and Assembly

13.6 Stages of Translation

Chapter 14 Gene Regulation in Bacteria

14.1 Overview of Transcriptional Regulation

14.2 Regulation of the lac Operon

14.3 Regulation of the trp Operon

14.4 Translational and Posttranslational Regulation

14.5 Riboswitches

Chapter 15 Gene Regulation in Eukaryotes I: Transcriptional AND TRANSLATIONAL Regulation

15.1 Regulatory Transcription Factors

15.2 Chromatin Remodeling, Histone Variants, and Histone Modification

15.3 DNA Methylation

15.4 The ENCODE Project

15.5 Regulation of Translation

Chapter 16 Gene Regulation in Eukaryotes II: Epigenetics

16.1 Overview of Epigenetics

16.2 Heterochromatin: Function, Formation, Structure, and Maintenance

16.3 Epigenetics and Development

16.4 Paramutation

16.5 Epigenetics and Environmental Agents

Chapter 17 Non-coding RNAs

17.1 Overview of Non-coding RNAs

17.2 Non-coding RNAs: Effects on Chromatin Structure and Transcription

17.3 Non-coding RNAs: Effects on Translation, mRNA Degradation, and RNA Modifications

17.4 Non-coding RNAs and Protein Targeting

17.5 Non-coding RNAs and Genome Defense

17.6 Role of Non-coding RNAs in Human Diseases

Chapter 18 Genetics of Viruses

18.1 Virus Structure and Genetic Composition

18.2 Overview of Viral Reproductive Cycles

18.3 Bacteriophage Reproductive Cycle

18.4 HIV Reproductive Cycle

Chapter 19 Gene Mutation, DNA Repair, and Recombination

19.1 Effects of Mutations on Gene Structure and Function

19.2 Random Nature of Mutations

19.3 Spontaneous Mutations

19.4 Induced Mutations

19.5 DNA Repair

19.6 Homologous Recombination

Part V Genetic Technologies

Chapter 20 MOLECULAR Technologies

20.1 Gene Cloning Using Vectors

20.2 Polymerase Chain Reaction

20.3 DNA Sequencing

20.4 Gene Editing

20.5 Blotting Methods to Detect Gene Products

20.6 Methods for Analyzing DNA- and RNA-Binding Proteins

Chapter 21 Biotechnology

21.1 Uses of Microorganisms in Biotechnology

21.2 Genetically Modified Animals

21.3 Reproductive Cloning and Stem Cells

21.4 Genetically Modified Plants

Chapter 22 Genomics I: Analysis of DNA

22.1 Overview of Chromosome Mapping

22.2 Cytogenetic Mapping via Microscopy

22.3 Linkage Mapping via Crosses

22.4 Physical Mapping via Cloning and DNA Sequencing

22.5 Genome-Sequencing Projects

22.6 Metagenomics

Chapter 23 Genomics II: Functional Genomics, Proteomics, and Bioinformatics

23.1 Functional Genomics

23.2 Proteomics

23.3 Bioinformatics

Part VI Genetic Analysis of Individuals and Populations

Chapter 24 Medical Genetics

24.1 Inheritance Patterns of Genetic Diseases

24.2 Detection of Disease-Causing Alleles via Haplotypes

24.3 Genetic Testing and Screening

24.4 Prions

24.5 Human Gene Therapy

24.6 Personalized Medicine

Chapter 25 Genetic Basis of Cancer

25.1 Overview of Cancer

25.2 Oncogenes

25.3 Tumor-Suppressor Genes

25.4 Role of Epigenetics in Cancer

Chapter 26 Developmental genetics

26.1 Overview of Animal Development

26.2 Invertebrate Development

26.3 Vertebrate Development

26.4 Plant Development

26.5 Sex Determination in Animals

Chapter 27 Population Genetics

27.1 Genes in Populations and the Hardy-Weinberg Equation

27.2 Overview of Microevolution

27.3 Natural Selection

27.4 Genetic Drift

27.5 Migration

27.6 Nonrandom Mating

27.7 Sources of New Genetic Variation

Chapter 28 COMPLEX AND Quantitative TRAITS

28.1 Overview of Complex and Quantitative Traits

28.2 Statistical Methods for Evaluating Quantitative Traits

28.3 Polygenic Inheritance

28.4 Identification of Genes That Control Quantitative Traits

28.5 Heritability

28.6 Selective Breeding

Chapter 29 Evolutionary Genetics

29.1 Origin of Species

29.2 Phylogenetic Trees

29.3 Molecular Evolution

Glossary

Appendix A

Appendix B

Index

Robert J. Brooker (Ph.D., Yale University) received his B.A. in biology at Wittenberg University, Springfield, Ohio, in 1978. At Harvard, he studied lactose permease, the product of the lacY gene of the lac operon. He continues working on transporters at the University of Minnesota, where he is a Professor in the Department of Genetics, Cell Biology, and Development and has an active research laboratory. At the University of Minnesota, Dr. Brooker teaches undergraduate courses in biology, genetics, and cell biology. In addition to many other publications, he has written two undergraduate genetics texts published by McGraw Hill.

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