Essential Cell Biology 5th INTERNATIONAL Edition by Bruce Alberts, ISBN-13: 978-0393680393

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Essential Cell Biology 5th INTERNATIONAL Edition by Bruce Alberts, ISBN-13: 978-0393680393

[PDF eBook eTextbook]

• Publisher: ‎ W. W. Norton & Company; Fifth INTERNATIONAL edition (July 1, 2019)
• Language: ‎ English
• 864 pages
• ISBN-10: 0393680398

• ISBN-13: 978-0393680393

This text features lively, clear writing and exceptional illustrations, making it the ideal textbook for a first course in both cell and molecular biology. Thoroughly revised and updated, the Fifth Edition maintains its focus on the latest cell biology research. For the first time ever, Essential Cell Biology will come with access to Smartwork5, Norton’s innovative online homework platform, creating a more complete learning experience.

Table of Contents:

CHAPTER 1 Cells: The Fundamental Units of Life 1

PANEL 1–1 Microscopy 12

TABLE 1–1 Historical Landmarks in Determining Cell Structure 24

PANEL 1–2 Cell Architecture 25

How We Know: Life’s Common Mechanisms 30

TABLE 1–2 Some Model Organisms and Their Genomes 35

CHAPTER 2 Chemical Components of Cells 39

TABLE 2–1 Length and Strength of Some Chemical Bonds 48

TABLE 2–2 The Chemical Composition of a Bacterial Cell 52

How We Know: The Discovery of Macromolecules 60

PANEL 2–1 Chemical Bonds and Groups 66

PANEL 2–2 The Chemical Properties of Water 68

PANEL 2–3 The Principal Types of Weak Noncovalent Bonds 70

PANEL 2–4 An Outline of Some of the Types of Sugars 72

PANEL 2–5 Fatty Acids and Other Lipids 74

PANEL 2–6 The 20 Amino Acids Found in Proteins 76

PANEL 2–7 A Survey of the Nucleotides 78

CHAPTER 3 Energy, Catalysis, and Biosynthesis 81

PANEL 3–1 Free Energy and Biological Reactions 94

TABLE 3–1 Relationship Between the Standard Free-Energy Change, G°, and the Equilibrium Constant 96

How We Know: “High-Energy” Phosphate Bonds Power Cell Processes 102

TABLE 3–2 Some Activated Carriers Widely Used in Metabolism 109

CHAPTER 4 Protein Structure and Function 117

PANEL 4–1 A Few Examples of Some General Protein Functions 118

PANEL 4–2 Making and Using Antibodies 140

TABLE 4–1 Some Common Functional Classes of Enzymes 142

How We Know: Measuring Enzyme Performance 144

TABLE 4–2 Historical Landmarks in Our Understanding of Proteins 160

PANEL 4–3 Cell Breakage and Initial Fractionation of Cell Extracts 164

PANEL 4–4 Protein Separation by Chromatography 166

PANEL 4–5 Protein Separation by Electrophoresis 167

PANEL 4–6 Protein Structure Determination 168

CHAPTER 5 DNA and Chromosomes 173

How We Know: Genes Are Made of DNA 193

CHAPTER 6 DNA Replication and Repair 199

How We Know: The Nature of Replication 202

TABLE 6–1 Proteins Involved in DNA Replication 213

TABLE 6–2 Error Rates 218

CHAPTER 7 From DNA to Protein: How Cells Read the Genome 227

TABLE 7–1 Types of RNA Produced in Cells 232

TABLE 7–2 The Three RNA Polymerases in Eukaryotic Cells 235

How We Know: Cracking the Genetic Code 246

TABLE 7–3 Antibiotics That Inhibit Bacterial Protein or RNA Synthesis 256

TABLE 7–4 Biochemical Reactions That Can Be Catalyzed by Ribozymes 261

CHAPTER 8 Control of Gene Expression 267

How We Know: Gene Regulation—The Story of Eve 280

CHAPTER 9 How Genes and Genomes Evolve 297

TABLE 9–1 Viruses That Cause Human Disease 318

TABLE 9–2 Some Vital Statistics for the Human Genome 322

How We Know: Counting Genes 324

CHAPTER 10 Analyzing the Structure and Function of Genes 333

How We Know: Sequencing the Human Genome 348

CHAPTER 11 Membrane Structure 365

TABLE 11–1 Some Examples of Plasma Membrane Proteins and Their Functions 375

How We Know: Measuring Membrane Flow 384

CHAPTER 12 Transport Across Cell Membranes 389

TABLE 12–1 A Comparison of Ion Concentrations Inside and Outside a Typical Mammalian Cell 391

TABLE 12–2 Some Examples of Transmembrane Pumps 403

How We Know: Squid Reveal Secrets of Membrane Excitability 412

TABLE 12–3 Some Examples of Ion Channels 419

CHAPTER 13 How Cells Obtain Energy from Food 427

TABLE 13–1 Some Types of Enzymes Involved in Glycolysis 431

PANEL 13–1 Details of the 10 Steps of Glycolysis 436

PANEL 13–2 The Complete Citric Acid Cycle 442

How We Know: Unraveling the Citric Acid Cycle 444

CHAPTER 14 Energy Generation in Mitochondria and Chloroplasts 455

TABLE 14–1 Product Yields from Glucose Oxidation 469

PANEL 14–1 Redox Potentials 472

How We Know: How Chemiosmotic Coupling Drives ATP Synthesis 476

CHAPTER 15 Intracellular Compartments and Protein Transport 495

TABLE 15–1 The Main Functions of Membrane-enclosed Organelles of a Eukaryotic Cell 497

TABLE 15–2 The Relative Volumes and Numbers of the Major Membrane-enclosed Organelles

in a Liver Cell (Hepatocyte) 498

TABLE 15–3 Some Typical Signal Sequences 502

TABLE 15–4 Some Types of Coated Vesicles 513

How We Know: Tracking Protein and Vesicle Transport 520

CHAPTER 16 Cell Signaling 533

TABLE 16–1 Some Examples of Signal Molecules 536

TABLE 16–2 Some Foreign Substances That Act on Cell-Surface Receptors 544

TABLE 16–3 Some Cell Responses Mediated by Cyclic AMP 550

TABLE 16–4 Some Cell Responses Mediated by Phospholipase C Activation 552

How We Know: Untangling Cell Signaling Pathways 563

CHAPTER 17 Cytoskeleton 573

TABLE 17–1 Drugs That Affect Microtubules 584

How We Know: Pursuing Microtubule-associated Motor Proteins 588

TABLE 17–2 Drugs That Affect Filaments 594

CHAPTER 18 The Cell-Division Cycle 609

TABLE 18–1 Some Eukaryotic Cell-Cycle Durations 611

How We Know: Discovery of Cyclins and Cdks 615

TABLE 18–2 The Major Cyclins and Cdks of Vertebrates 617

PANEL 18–1 The Principal Stages of M Phase in an Animal Cell 628

CHAPTER 19 Sexual Reproduction and Genetics 651

PANEL 19–1 Some Essentials of Classical Genetics 675

How We Know: Using SNPs to Get a Handle on Human Disease 684

CHAPTER 20 Cell Communities: Tissues, Stem Cells, and Cancer 691

TABLE 20–1 A Variety of Factors Can Contribute to Genetic Instability 721

TABLE 20–2 Examples of Cancer-critical Genes 728

How We Know: Making Sense of the Genes That Are Critical for Cancer 730

Bruce Alberts received his PhD from Harvard University and is the Chancellor’s Leadership Chair in Biochemistry and Biophysics for Science and Education, University of California, San Francisco. He was the editor in chief of Science magazine from 2008 until 2013, and for 12 years he served as president of the U.S. National Academy of Sciences (1993–2005).

Rebecca Heald is an American professor of cell and developmental biology. She is currently a professor in the Department of Molecular and Cell Biology at the University of California, Berkeley. In May 2019, she was elected to the National Academy of Sciences.

Karen Hopkin received her PhD in biochemistry from the Albert Einstein College of Medicine and is a science writer in Somerville, Massachusetts. She is a regular columnist for The Scientist and a contributor to Scientific American’s daily podcast, “60-Second Science.”

Alexander Johnson received his PhD from Harvard University and is a professor of microbiology and immunology at the University of California, San Francisco. He is a member of the National Academy of Sciences.

David Morgan received his PhD from the University of California, San Francisco, and is a professor in the Department of Physiology as well as the vice dean for research for the School of Medicine. Dave is a fellow of the Royal Society of London.

Keith Roberts received his PhD from the University of Cambridge and was deputy director of the John Innes Centre, Norwich. He is emeritus professor at the University of East Anglia. Keith was recipient of the Order of British Empire for his service to sciences.

Peter Walter received his PhD from the Rockefeller University in New York, is a professor in the Department of Biochemistry and Biophysics at the University of California, San Francisco, and is an investigator at the Howard Hughes Medical Institute. He is a member of the National Academy of Sciences.

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